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In an open uncontrolled trial in 20 men with idiopathic infertility and a low testosterone-to-estrogen ratio, three months of treatment with letrozole resulted in improved sperm motility and morphology, reduced sperm DNA fragmentation, increased testosterone-to-estrogen ratio, and four spontaneous pregnancies

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This increasing pro-inflammatory mediator expression is associated with the phosphorylation of MAPKs within 1530 min after LPS stimulation (4648)