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The copper component can cause localized burning, redness, or irritation in some individuals

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Symptoms like dizziness, confusion, and weakness may occur, and long term use could contribute to insulin resistance, increasing the risk of metabolic disorders

The latter suffer -oxidation in the liver to produce phenylacetic acid that is conjugated with glutamine in the liver and kidney, forming phenylacetyl glutamine that is then excreted in urine