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The retatrutide versus semaglutide comparison highlights just how much more aggressive the weight loss trajectory may be, which could have implications for how aggressively providers prescribe to patients at lower BMI ranges

So a thorough patient history is essential, especially since obesity is a risk factor in and of itself for pancreatitis

(Learn more here about how to eat well on GLP-1s.) Unfortunately, these medications are not without side effects, such as nausea and stomach discomfort

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Aggressive hydration is also critical to manage renal load and prevent dehydration from suppressed thirst mechanisms