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It is only the recent successes of the GLP-1 receptor agonists that have really underpinned this work. Holst, professor of medical physiology in the department of biomedical sciences and vice chair of the faculty of health sciences at the University of Copenhagen, has spent his career studying the regulatory peptides of the pancreas and the gut and their importance in the regulation of the functions of the gastrointestinal tract and metabolism, with a focus recently on the incretin hormones GLP-1 and GIP

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Historically, peptides like semaglutide could not be taken orally because the stomachs acidic environment would degrade them before they could be absorbed