Shiramizu, B
Its been primarily studied by a Croatian team [experimenting on] rodents
Additionally, excessive reactive oxygen species (ROS) are another important impediment to the diabetic wound healing process, causing perpetual and irreversible damage to biomolecules and sustaining macrophages in the M1 phenotype to exacerbate the inflammatory response 7,8,9
Two weeks is the minimum for meaningful recovery
The administration of System X c inhibitors can deplete intracellular cysteine, reduce GSH concentration, trigger OS, and increase cell sensitivity to ferroptosis ( Small molecule erastin can directly and selectively target and inhibit the System X c , and irreversibly bind to and inactivate XCT, leading to continuous disorder of cystine uptake, a decrease in cellular antioxidant capacity, and eventually ROS accumulation and ferroptosis (Sato et al., 2018