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6-months of treatment with the GLP-1R agonist liraglutide (Victoza ) in Alzheimers disease patients was found to prevent declines in cerebral glucose metabolism, which is associated with synaptic dysfunction, cognitive impairment, and progression of the disease (Gejl et al., 2016) (Table 5)

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The FBXO22 FIST constructs (WT and variants) harbored a C-terminal Twin-Strep tag and were expressed without SKP1 in Tni cells

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