Key limitations: Some compounds have direct human pharmacodynamic data
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CR, or the reduction of daily caloric intake without malnutrition (~20%), has been repeatedly associated with a decrease in cancer incidence in animal models since the very early 20th century (46), including in primates (47, 48)
Last reviewed: May 25, 2026 Last updated: May 25, 2026 Written by: Jay Hastings, CEO of PlexusDx Jay Hastings is the CEO of PlexusDx, a precision health company focused on genetic testing, blood biomarker insights, and personalized wellness recommendations