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Furthermore, it highlights the role of NAD + in mitochondrial homeostasis in aging and disease conditions, the latest results of NAD + -boosting therapeutics in clinical trials, and areas of further translational development

Valproate Valproate ( valproic acid , VPA , sodium valproate , and valproate semisodium forms) are medications primarily used to treat epilepsy and as a mood stabilizer in the treatment of bipolar disorder

Hongqing Zhou (zhouhongqing

The future lies in developing allosteric modulators or subunit-selective antagonists (particularly for GluN2B-containing receptors) that can precisely modulate pathological hyperactivity in the auditory pathway without disrupting essential NMDA receptor functions elsewhere in the brain, thereby offering a more effective and tolerable treatment strategy for tinnitus (Rafe et al., 2024

The substitution of D-alanine at position 2 reduces susceptibility to enzymatic cleavage