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Although fatigue prevalence fluctuates concerning cirrhosis etiology, ranging from 44% in autoimmune liver disease to as high as 80% in primary biliary cholangitis (7), it is noteworthy that this symptom may not necessarily correlate with the severity of underlying liver fibrosis, advanced disease stages, or organ dysfunction

Unlike many classical peptide hormones, thymosin-4 does not signal through a well-defined GPCR or receptor tyrosine kinase

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