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Trials looking that ability of MK677 to reverse AD have been disappointing, but this is likely because the accumulation of amyloid beta has already had serious negative impact by the time the brain reaches AD

Funding This work was supported by the National Natural Science Foundation of China (32070925 to Qinjian Zhao and 82371832 to Xiao Zhang), Natural Science Foundation of Chongqing City (2023NSCQ-MSX1536 to Xiao Zhang), Natural Science Foundation of Fujian Province (2023J011235 to Xiao Zhang), Chongqing Education Commission of Science and Technology Research Project (KJQN202300453 to Xiao Zhang)

Key Areas of Research: Molecular GHRH-receptor binding kinetics

Genome Res 19:15071515 Tujios S, Fontana RJ (2011) Mechanisms of drug-induced liver injury: from bedside to bench

MASLD is diagnosed when hepatic steatosis occurs in combination with cardiometabolic risk factors, including overweight/obesity, elevated blood pressure, atherogenic dyslipidemia, prediabetes, or T2DM (Targher et al., 2021[75], 2025[79]