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Their biological effects may be inappropriate for generalized metabolic disease but highly relevant for behaviorally mediated subtypes, reinforcing the need for stratified translational strategies

It may also help increase levels of this important compound

"Triple Hormone Receptor Agonist Retatrutide for Metabolic Dysfunction-Associated Steatotic Liver Disease: a randomised, double-blind, placebo-controlled, phase 2a trial." Nature Medicine , 2024