The antimicrobial efficacy of these compounds ranged from strong to moderate
Any immune or inflammatory settings in which the amount or activity of any of these proteins is lowered or does not increase appropriately (as we modeled with erastin) could dramatically perturb homeostatic balance and enhance T2 inflammatory factor expression and oxidatively driven cell death
Am J Respir Crit Care Med 171 : 431439 Fitzpatrick AM, Brown LA, Holguin F, Teague WG, National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program 2009 Levels of nitric oxide oxidation products are increased in the epithelial lining fluid of children with persistent asthma
Exploratory research discussions often involve evaluation within cellular and biochemical models associated with oxidative stress regulation, intracellular balance, and enzymatic activity
When to decrease dose Consider decreasing if: Persistent side effects that don't resolve Excellent results achieved and maintenance desired Budget constraints require conservation Stacking and wanting to optimize ratios Many researchers find they can reduce dose during maintenance phases after achieving initial goals during more intensive loading phases
