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Research indicates that individuals with severe depression exhibit lower ATP and glucose metabolism in brain regions associated with mood regulation, including the bilateral insula, nucleus accumbens, and cingulate gyrus (Su et al., 2014)

NLRP3 also influences macrophage polarization, ensuring timely transition from pro-inflammatory to pro-repair phenotypes

doi: 10.1002/jps.23018

NAD + mitigates viral infection-induced oxidative damage Oxidative stress is implicated as a pathogenic factor in viral infection

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