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Dysmenorrhea is the hallmark of endometriosis

Corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) secreted by the hypothalamus act on the anterior pituitary and accelerate the release of adrenocorticotropic hormone (ACTH) and its stimulation of the adrenal cortex, further triggering the secretion of cortisol and other hormones and ultimately reaching the target site through blood circulation, affecting the functional and immune states of the intestinal tract (111)

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Over 80% of those who develop REM Sleep Behavior Disorder also progress to develop a neurodegenerative disorder that is an a-synucleinopathy

Studies on other cancer types have shown that TMAO can affect cellular metabolism and signaling pathways associated with drug resistance