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The article says expiration dates vary by pharmacy and by formulation, and that stability depends on formulation type, vehicle ingredients and storage conditions

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47 During the initial phase of CR interventions, serum markers of bone turnoversuch as osteocalcin, C-terminal telopeptide of type I collagen (CTX), and N-terminal telopeptide (NTX)increase significantly, reflecting an acceleration of bone resorption

But also from a psychological perspective, purposefully manipulating internal signals of hunger and fullness can lead to a sense of distrust towards peoples own bodies, which arguably is one of the underlying causes of a problematic relationship with food

10.1016/0024-3205(88)90468-7 112 SmithS