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On the other hand, Daily administration of l-carnitine (200 mg/kg/day) for 28 days resulted in a significant 25% increase in total carnitine level in cardiac tissues and non-significant change in serum carnitine level, as compared to control group

Post-Market Surveillance Gap: Because AOD-9604 never received FDA approval for any indication, there is no post-market surveillance system capturing safety signals from widespread clinical use

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By inhibiting the Gas proteins and facilitating receptor trafficking through internalization and recycling, these beta arrestins are essential for GIP receptor desensitization