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In studies using human fetal fibroblast cultures, Epithalon treatment extended cellular proliferative potential from termination at the 34th passage in control populations to beyond the 44th passage in treated cells, effectively surpassing the Hayflick limitthe maximum number of divisions normal cells can undergo before senescence

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In addition, DHAR, CLIC1 and GSTOs commonly contain a highly conserved catalytic cysteine residue and GSH binding residues near the active site