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On balance, the beneficial associations for GLP-1 drugs were stronger, more numerous, and generally related to more serious health outcomes than the negative associations

Less commonly, temporary headaches, nausea, or gastrointestinal upset may occur

In July 2020, the patient self-ordered an intestinal antigenic permeability screen (Cyrex array), which showed increased levels of occludin/zonulin IgA, lipopolysaccharide (LPS) IgG, and IgA, indicating a leaky gut

Each component addresses a different limitation of GLP-1 monotherapy, and the combination produces an effect profile that none of the three could achieve alone

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