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Intracellular G-protein-coupled receptors, particularly the trace amine-associated receptor 1 (TAAR1), function as internal sensors of cytoplasmic catecholamines and their metabolites (Underhill et al., 2021)

In certain cases, a healthcare professional may prescribe treatments such as biofeedback therapy, surgery, or transanal irrigation with a water enema ( In addition to these treatments, evidence suggests that certain supplements may help reduce constipation symptoms

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