T2DM is a chronic metabolic disease associated with hyperglycemia due to insulin resistance (IR), and is increasingly recognized as a key factor in the onset and progression of PD
10.1167/iovs.15-18066 34 LuQ.LiuY.WangY.WangW.YangZ.LiT.et al (2017)
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Clinical trial data shows meaningful weight loss in the first 12 weeks of GLP-1 treatment, though results vary significantly based on starting weight, the specific medication, dose, dietary choices, and activity level
Furthermore, the relevance of this environment-diet-gene interaction to the patho-aetiology of contemporary disease needs to be explored with a considered approach, taking into account interactions between skin pigmentation, UVR exposure, folate status and folate-related gene epistasis