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Isoform specificity One way in which therapeutics against glutamine metabolism could be made more specific is by developing drugs against the particular isoforms of metabolic enzymes that are required in each tumour type, especially isoforms that are not commonly expressed in normal tissues

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Fraternale A, Paoletti MF, Casabianca A, Oiry J, Clayette P, Vogel JU, Cinatl J Jr, Palamara AT, Sgarbanti R, Garaci E, Millo E, Benatti U, Magnani M

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