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It adds that animal reproduction studies suggest potential risk while human data is absent, and that this uncertainty is what drives the conservative clinical recommendations that follow

The bilateral STNs were the targeted regions for DBS, localized through presurgical structural MRI scans, intraoperative electrophysiological recordings and observed motor symptom improvement during the surgery

Buresova I, Hricova D, Mullerova J

HYPOGLYCAEMIA RISK ADDITIVE WITH: Sulfonylureas (glibenclamide, glipizide, glimepiride, gliclazide): increased hypoglycaemia risk consider reducing sulfonylurea dose when initiating Rybelsus Insulin: significant hypoglycaemia risk consider insulin dose reduction and increase glucose monitoring frequency Meglitinides (repaglinide, nateglinide): additive hypoglycaemia risk 2