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They exert direct positive impacts on the coronary vascular endothelium, such as oxidative stress reduction and increase in nitric oxide, which at least partially account for their antihypertensive and antiatherosclerotic properties (39)

The short answer: same day is fine, different injection sites are required, same syringe is not allowed

GLP-1R Agonists Modulate Enteric Immune Responses Through the Intestinal Intraepithelial Lymphocyte GLP-1R

Glucagonlike peptide 1 analogue prevents cholesterol gallstone formation by modulating intestinal farnesoid X receptor activity

The first time we saw this was during the liraglutide trials where blood pressure reduction occurred within 2 weeks of initiation of therapy, which was before any meaningful weight benefit was demonstrated suggesting that weight loss is not the driver of the blood pressure benefits