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PMID: 72 DingHZhangJZhangFZhangSChenXLiangWet al

In the STEP-1 trial, participants taking semaglutide 2.4 mg weekly (Wegovy) lost an average of 14.9% of their body weight over 68 weeks, with significant reductions in waist circumference averaging 13.5 cm (about 5.3 inches)

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Common early side effects like nausea, constipation, or reduced appetite for favorite foods are typically mild and temporary, resolving within 1-2 weeks