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More recently, the use of IPI504 (Retaspimycin, a synthetic derivative of Geldanamycin), in an in vitro model of age-related macular degeneration (AMD) on senescent ARPE-19 (human arising retinal pigment epithelial cells), leads to a decrease of SA--Galactosidase positive cells, associated with a downregulation of senescence-associated gene expression as well as SASPs secretion, suggesting that in some cases HSP90 inhibitors could also be used as senomorphics 27

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p38 and extracellular signal-regulated kinases regulate the myogenic program at multiple steps

Acta Physiol Scand (2003) 177(4):43747

Interestingly, compared to the two single mutants, the reduction in aliphatic GSLs was further exaggerated in the double mutant (Figures 6A,C)