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Por accin de la enzima trimetil lisina dioxigenasa (TML-DO, EC 1.14.11.8) se hidroxila la posicin 3 de la TML para formar la 3-hidroxi- N 6 , N 6 -trimetil lisina ( HTML ) en presencia de oxgeno diatmico como agente oxidante, -cetoglutarato como aceptor de electrones, adems de hierro (II) y cido ascrbico como cofactores
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Key R&D Programs of Hunan Province (grant number 2019SK2241)
Los sntomas incluyen dolor de la parte baja del estmago (abdominal), especialmente en el lado izquierdo, posiblemente con fiebre y estreimiento
Endothelial dysfunction, dysregulation of ER stress and autophagy pathways, mitochondrial toxicity, calcium imbalance, and several other side effects have also been observed in kidneys, the gut, major arteries, liver, and other organs (Apostolova et al
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