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Phase 1/2 study of ARV-110, an androgen receptor (AR) PROTAC degrader, in metastatic castration-resistant prostate cancer (mCRPC)

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The 1st glutathione-interaction site, also termed glutathione-scaffold site, is rather well defined and comprises several protein areas that altogether contribute to catalysis by interacting with the glutathione moiety of GSSR 7,8,13,14,15,35 , therefore explaining the specificity for the -glutamyl moiety 9,49,50

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[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Yang Z, Lv Y, Yu M, Mei M, Xiang L, Zhao S, et al