tirzepatide works better than semaglutide caused roughly half as many patients to stop treatment because of gastrointestinal side effects as semaglutide. In the first major head-to-head obesity trial, GI side effects caused treatment discontinuation in: Tirzepatide Semaglutide vs. Tirzepatide for Weight

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Many patients stop taking semaglutide within a few months after they start

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