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Following a second administration of Donor+Cas9, plasma Exe4 levels increased and remained elevated for over 28 weeks, doubling the level of Exe4 production and secretion compared to a single administration, suggesting the potential for fine-tuning the regimen dose through repetitive administration (Supplementary Fig

As an inherent skeptic, I immediately assumed this must be a placebo affect

Wu J, Vodovotz Y, Abdelhamid S, Guyette FX, Yaffe MB, Gruen DS, et al

Importantly, none of the trials in T1D reported an increase in diabetic ketoacidosis (DKA) a key concern that has limited the use of SGLT2 inhibitors in T1D