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Garvey WT, Ryan DH, Bohannon NJ, et al

Hypotension consider reducing antihypertensive medicines before initiating treatment or before a dose increase Diabetic ketoacidosis (DKA) increased risk (see below) SGLT-2 inhibitor use is associated with an increased risk of severe DKA People taking SGLT-2 inhibitors are at increased risk of DKA, particularly in the first few months of treatment or peri-operatively

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Clinical Trial Results: The Numbers That Matter The Phase 2 clinical trial published in the New England Journal of Medicine provided the foundational data driving interest in Retatrutide

Understanding both the potential and the significant limitations is essential when evaluating compounds that operate in the research and gray-market space