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Side Effects and Tolerability: What to Expect Both tirzepatide and semaglutide commonly cause nausea, constipation, and reduced appetite during the first 24 weeks as your digestive system adapts

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Since semaglutide slows down the movement of food through your intestines, your body has more time to absorb water from the waste

Aplenzin can cost upwards of $2500 for a month's supply