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This can be associated with conditions like: Sarcoidosis Systemic Lupus Erythematosus (SLE) Infections Less commonly, optic neuritis can be caused by various infections, including: Viral infections (e.g., measles, mumps, rubella) Bacterial infections (e.g., Lyme disease, syphilis) Fungal infections Idiopathic Cases In many instances, the exact cause of optic neuritis remains unknown