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While the neuroprotective effect in preclinical studies is clear, clinical findings have so far failed to demonstrate an arresting effect on cognitive

25 The denominator was calculated as the predicted probability (1 minus the survival probability) of either initiating or discontinuing SGLT2i use, using baseline covariables and time-dependent covariables (the numerator was calculated using an empty model)

We then compared those numbers to some of the other options out there, and were shocked by the data

10.1017/s0265021505210141 Eur