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DSIP crosses the blood-brain barrier freely an unusual property for a peptide of its size via a non-competitive, non-saturable passive mechanism whose physicochemical determinants (lipophilicity, charge, molecular weight, and protein-binding) are now well characterised

Starr ME, Evers BM, Saito H

Biochemical changes : Caused significant liver damage and necrosis of cells as evidenced by the elevated serum hepatic enzymes ALT, AST, ALP, and GT

The bioenergetic demands of intense performance place substantial loss of ability to regulate energy balance

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