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The EMA and Member States pushed communication campaigns, but the structural problem remained: a mandatory hard deadline for thousands of trial transitions converged on a system that had known capacity constraints from the day it launched

GCSI Scoring System for Patient-Reported Outcomes The GCSI is a patient-based symptom instrument in which the score is a sum of three subscale scores (each ranging from 1 to 3) for the three main symptom complexes: 1

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Hydration and sun protection: Help maintain elasticity