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The primary mechanism of action involves several complementary pathways: Glucose-dependent insulin secretion : GLP-1 agonists stimulate pancreatic beta cells to release insulin only when blood glucose levels are elevated, reducing the risk of hypoglycaemia compared to some other diabetes medications
Clinical trials have included both male and female participants, with some notable observations: Metabolic differences Men typically have higher baseline metabolic rates and different fat distribution patterns, which may influence response magnitude but not optimal dosing protocols
J Pediatr (2006) 149(1):4752
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