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Yanovski, S.Z

No outside honorarium, grant or other form of payment was given to anyone to produce the manuscript

Kaufman, D

Additionally, GPxs due to their subcellular compartmentalization (cytoplasmic, membrane, ER, and mitochondrial localizations) control the local concentration gradient of peroxides and thereby regulate the activation/deactivation of redox-responsive signaling pathways [1, 8,9,10]

Doses below 200mcg may not produce sufficient GH pulse amplitude to drive metabolic changes, while doses above 500mcg dont appear to increase response magnitude based on clinical trial data