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Why the Difference Creates Synergy Because the two compounds engage GH release through separate, complementary mechanisms, activating both at once is studied for a synergistic effect a combined GH response greater than the sum of either alone

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However, in the non-senescent control fibroblast model cultured in 10% FBS DMEM treated with or without FOXO4-DRI (25 M), no SA--gal-positive cells were observed both in keloid fibroblasts and in normal skin fibroblasts (Supplementary Fig

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